
Overview:
HO2,orhemeoxygenase2,belongstothehemeoxygenasefamilythatareessentialenzymeinhemecatabolismthatcleavehemetoformbiliverdinwhichissubsequentlyconvertedtobilirubinbybiliverdinreductase(1).HO2ispartofthecalcium-sensitivepotassiumchannelcomplexandenhanceschannelactivityinnormoxia(2).KnockdownofHO2expressionreduceschannelactivity,aneffectthatisreversedbycarbonmonoxide.Inhibitionofcalcium-sensitivepotassiumchannelsbyhypoxiaisdependentonHO2expressionandisaugmentedbyHO2stimulation.
GeneAliases:
HMOX2
GenbankNumber:
NM_002134
References:
1.Kemp,P.J.etal:Hemeoxygenase-2asanO2sensorinK+channel-dependentchemotransduction.BiochemBiophysResCommun.2005;338(1):648-52.2.Williams,S.E.etal:Hemoxygenase-2isanoxygensensorforacalcium-sensitivepotassiumchannel.Science.2004Dec17;306(5704):2093-7.
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算上其他生物24种
大概是记不太清了

