
Overview:
Mortalinisamitochondrialchaperoneandamemberoftheheatshockprotein70familythatisconstitutivelyexpressedincells.Mortalinplaysacentralroleinmitochondrialbiogenesisthroughitscapacitytodirecttheimportofnuclear-encodedproteinsintothemitochondria.Mortalinplaysaroleinthecontrolofcellproliferationandelevatedlevelsofmortalinhavecorrelatedwithmalignanttransformationandpoorcancerprognosis.Mortalincansupportcancercellresistancetocomplement-dependentcytotoxicity(1).MortalinexpressionwasdecreasedinthemitochondrialfractionofneuronsfromthesubstantianigraofParkinsondiseasepatients(2).
GeneAliases:
HSPA9;CSA;GRP75;HSPA9B;MGC4500;MOT;mot-2;MOT2;MTHSP75;PBP74
GenbankNumber:
NM_004134
References:
1.Pilzer,D.etal:MortalininhibitorssensitizeK562leukemiacellstocomplement-dependentcytotoxicity.IntJCancer.2010Mar15;126(6):1428-35.2.DeMena,L.etal:Mutationalscreeningofthemortalingene(HSPA9)inParkinson"sdisease.JNeuralTransm.2009Oct;116(10):1289-93.
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算上其他生物24种
大概是记不太清了

