
Overview:
TPM3ortropomyosin3isamemberofthetropomyosinfamilyofactin-bindingproteinsthataredimersofcoiled-coilproteinsthatprovidestABIlitytoactinfilamentsandregulateaccessofotheractin-bindingproteins.TPM3involvedintranslocationswithotherloci,includinganaplasticlymphomareceptortyrosinekinase(ALK)andneurotrophictyrosinekinasereceptortype1(NTRK1),whichresultintheformationoffusionproteinsthatactasoncogenes.TPM3proteinissubstitutedfortheexternaldomainofaputativetyrosine-kinasecellsurfacereceptortocreatetheTRKoncogene(1).TPM3areacommoncauseofcongenitalfibertypedisproportion(2).
GeneAliases:
APM1;CFTD;hscp30;NEM1;OK/SW-cl.5;TM-5;TM3;TM30;TM30nm;TM5;TPMsk3
GenbankNumber:
NM_152263
References:
1.Coulier,F.et.al:MechanismofactivationofthehumanTRKoncogene.Molec.Cell.Biol.9:15-23,1989.2.Clarke,N.F.et.al:MutationsinTPM3areacommoncauseofcongenitalfibertypedisproportion.Ann.Neurol.63:329-337,2008.
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算上其他生物24种
大概是记不太清了

