Overview:
TPM3ortropomyosin3isamemberofthetropomyosinfamilyofactin-bindingproteinsthataredimersofcoiled-coilproteinsthatprovidestABIlitytoactinfilamentsandregulateaccessofotheractin-bindingproteins.TPM3involvedintranslocationswithotherloci,includinganaplasticlymphomareceptortyrosinekinase(ALK)andneurotrophictyrosinekinasereceptortype1(NTRK1),whichresultintheformationoffusionproteinsthatactasoncogenes.TPM3proteinissubstitutedfortheexternaldomainofaputativetyrosine-kinasecellsurfacereceptortocreatetheTRKoncogene(1).TPM3areacommoncauseofcongenitalfibertypedisproportion(2).
GeneAliases:
APM1;CFTD;hscp30;NEM1;OK/SW-cl.5;TM-5;TM3;TM30;TM30nm;TM5;TPMsk3
GenbankNumber:
NM_152263
References:
1.Coulier,F.et.al:MechanismofactivationofthehumanTRKoncogene.Molec.Cell.Biol.9:15-23,1989.2.Clarke,N.F.et.al:MutationsinTPM3areacommoncauseofcongenitalfibertypedisproportion.Ann.Neurol.63:329-337,2008.
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本人目前需从电鳗放电器官中提取乙酰胆碱受体蛋白,提纯需要的步骤和电鳗器官都可以提供,有没有提供外包提纯服务的公司或者实验室。
算上其他生物24种
大概是记不太清了
NaturalProteinStopsDeadlyHumanBrainCancerInMice
ScientistsfromJohnsHopkinsandfromtheUniversityofMilanhaveeffectivelyproventhattheycaninhibitlethalhumanbraincancersinmiceusingaproteinthatselectivelyinducespositivechangesintheactivityofcellsthatbehavelikecancerstemcells.ThereportispublishedinNature.
Themostcommontypeofbraincancer-glioblastoma-ismarkedbythepresenceofthesestem-cell-likebraincells,which,insteadoftriggeringthereplacementofdamagedcells,formcancertissue.Stemcells,unlikeallothercellsinthebody,arecapableofformingalmostanykindofcellwhentheright"signals"triggertheirdevelopment.
Fortheirtreatmentexperiment,theresearchersreliedonaclassofproteins,bonemorphogenicproteins,thatcauseneuralstem-cell-likeclusterstolosetheirstemcellproperties,whichinturnstopstheirABIlitytodivide.
Firsttheypretreatedhumanglioblastomacellswithbonemorphogenicprotein4(BMP4),theninjectedthesetreatedcellsintomousebrains.Inmiceinjectedwithcellsthatwerenotpretreated,large,invasivecancersgrew.InthemicewithBMP4-treatedcells,nocancersgrewatall.Threetofourmonthsafterinjection,allmicethatgotuntreatedcellsdied,andnearlyallmicewithBMP4-treatedcellswerealive.
Next,thescientistsdeliveredslow-releaseBMP4-containing"beads"directlyintomousebrainswithimplantedglioblastomacells.Micethatgotemptybeadsdevelopedlargemalignanttumorsanddied.MicewithBMP4beadssurvivedmuchlonger,and80percentsurvivedfourmonthsaftercancercellimplants.
"OurideaistotreatpatientswithBMP4orsomethinglikeitrightaftersurgerytoremoveglioblastomainhopesofpreventingtheregrowthofthecancerandimprovingsurvivaltime,"saysAlessandroOlivi,M.D.,directoroftheDivisionofNeurosurgicalOncologyatHopkinsandacontributortothestudy.
OlivisaysclinicalstudiesusingBMP4couldbeginwithinayearand,ifsuccessful,drugtherapiescouldbeavailabletothepublicwithinthreetofouryears.
"ThiswasproofoftheideathatBMPscouldstopglioblastomabydepletingthestem-cell-likepopulationthatfeedsit,"saysHenryBrem,M.D.,chairmanoftheDepartmentofNeurosurgeryatHopkinsandacollaboratorinthestudy."Thisopensexcitingdoorstofutureresearchintotreatmentsandtherapiesforsuchadevastatingdisease."

