Tocris一级代理 Tocris Bioscience抗体品牌,Tocris/Jasplakinolide/2792/100U/100 ug,其它天然蛋白,天然蛋白,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/Jasplakinolide/2792/100U/100 ug

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2792/100U

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Description:StABIlizesF-actin;promotesactinpolymerization

ChemicalName:Cyclo[(3R)-3-(4-hydroxyphenyl)-β-alanyl-(2S,4E,6R,8S)-8-hydroxy-2,4,6-trimethyl-4-nonenoyl-L-alanyl-2-bromo-N-methyl-D-tryptophyl]

Purity:≥97%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Rapidlystabilizespre-formedactinfilamentsandinhibitstheirdisassemblyinvitro.AlsoinducespolymerizationofactinmonomersintoF-actininvivo.ShowntobindtoF-actincompetitivelywithphalloidin(Cat.No.4535)(K_d~15nM).Exhibitsantifungalandantiproliferativeeffects(IC₅₀=35nMforantiproliferativeactivityinPC3cells).Cellpermeable.

TechnicalData

M.Wt	709.67
Formula	C₃₆H₄₅BrN₄O₆
Storage	Storeat-20°C
Purity	≥97%(HPLC)
CASNumber	102396-24-7
PubChemID	9831636
InChIKey	GQWYWHOHRVVHAP-DHKPLNAMSA-N
Smiles	C[C@H](C[C@H](C)OC1=O)/C=C(C)/C[C@H](C)C(N[C@H](C(N([C@H](CC2=C(Br)NC3=C2C=CC=C3)C(N[C@@H]([C@]4=CC=C(O)C=C4)C1)=O)C)=O)C)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	2	3

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight709.67.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.41mL	7.05mL	14.09mL
5mM	0.28mL	1.41mL	2.82mL
10mM	0.14mL	0.7mL	1.41mL
50mM	0.03mL	0.14mL	0.28mL

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