BiologicalActivity
Rapidlystabilizespre-formedactinfilamentsandinhibitstheirdisassemblyinvitro.AlsoinducespolymerizationofactinmonomersintoF-actininvivo.ShowntobindtoF-actincompetitivelywithphalloidin(Cat.No.4535)(Kd~15nM).Exhibitsantifungalandantiproliferativeeffects(IC50=35nMforantiproliferativeactivityinPC3cells).Cellpermeable.
TechnicalData
| M.Wt | 709.67 |
| Formula | C36H45BrN4O6 |
| Storage | Storeat-20°C |
| Purity | ≥97%(HPLC) |
| CASNumber | 102396-24-7 |
| PubChemID | 9831636 |
| InChIKey | GQWYWHOHRVVHAP-DHKPLNAMSA-N |
| Smiles | C[C@H](C[C@H](C)OC1=O)/C=C(C)/C[C@H](C)C(N[C@H](C(N([C@H](CC2=C(Br)NC3=C2C=CC=C3)C(N[C@@H]([C@]4=CC=C(O)C=C4)C1)=O)C)=O)C)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 2 | 3 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight709.67.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.41mL | 7.05mL | 14.09mL |
| 5mM | 0.28mL | 1.41mL | 2.82mL |
| 10mM | 0.14mL | 0.7mL | 1.41mL |
| 50mM | 0.03mL | 0.14mL | 0.28mL |
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