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Description:N-WASPinhibitor;inhibitsArp2/3activation
ChemicalName:3,6-Dibromo-α-[(dimethylamino)methyl]-9H-cabazole-9-ethanol
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
InhibitorofneuralWiskott-Aldrichsyndromeprotein(N-WASP)activity.InteractswiththeregulatoryGTPase-bindingdomainofN-WASP;inhibitsactivationofArp2/3complexbymaintainingN-WASPinaninactiveconformation.AlsoinhibitsPIP2-inducedactinpolymerization(EC50~4μM).
CompoundLibraries
WiskostatinisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
M.Wt | 426.15 |
Formula | C17H18Br2N2O |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 253449-04-6 |
PubChemID | 2775510 |
InChIKey | XUBJEDZHBUPBKL-UHFFFAOYSA-N |
Smiles | BrC(C=C3)=CC1=C3N(CC(O)CN(C)C)C2=C1C=C(Br)C=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 42.62 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight426.15.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.35mL | 11.73mL | 23.47mL |
5mM | 0.47mL | 2.35mL | 4.69mL |
10mM | 0.23mL | 1.17mL | 2.35mL |
50mM | 0.05mL | 0.23mL | 0.47mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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