BiologicalActivity
InhibitorofneuralWiskott-Aldrichsyndromeprotein(N-WASP)activity.InteractswiththeregulatoryGTPase-bindingdomainofN-WASP;inhibitsactivationofArp2/3complexbymaintainingN-WASPinaninactiveconformation.AlsoinhibitsPIP2-inducedactinpolymerization(EC50~4μM).
CompoundLibraries
WiskostatinisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 426.15 |
| Formula | C17H18Br2N2O |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 253449-04-6 |
| PubChemID | 2775510 |
| InChIKey | XUBJEDZHBUPBKL-UHFFFAOYSA-N |
| Smiles | BrC(C=C3)=CC1=C3N(CC(O)CN(C)C)C2=C1C=C(Br)C=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 42.62 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight426.15.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.35mL | 11.73mL | 23.47mL |
| 5mM | 0.47mL | 2.35mL | 4.69mL |
| 10mM | 0.23mL | 1.17mL | 2.35mL |
| 50mM | 0.05mL | 0.23mL | 0.47mL |
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