SDS-PAGE showing purified MOG protein (indicated by arrow).

- Images
- Technical documentation
- Description
- Shipping
Certificate of analysisSafety datasheet
MYELIN-OLIGODENDROCYTE GLYCOPROTEIN (MOG)
Recombinant MOG protein produced in HEK293 cells and purified from culture supernatant. Protein contains a C-terminal 6x His-tag.
PRODUCT DETAILS – MYELIN-OLIGODENDROCYTE GLYCOPROTEIN (MOG)
- Recombinant human myelin oligodendrocyte glycoprotein (MOG) expressed from HEK293 cells (NCBI Accession Number: NP_001008230.1).
- Includes amino acids 1-154 and a C-terminal His-tag.
- Greater than 90% purity by SDS-PAGE and buffered in DPBS, pH7.4.
BACKGROUND
Myelin oligodendrocyte glycoprotein (MOG) may play a key role in infectious disease. The cellular receptor for Rubella virus (RV) is currently unknown. However, MOG has been shown to bind specifically to the E1 envelope glycoprotein of RV and an antibody against MOG blocked RV infection. Ectopic expression of MOG on the cell surface of HEK293T cells also rendered this nonpermissive cell line permissive for RV entry and replication. Therefore, MOG is likely a host-cell receptor for RV which may offer new approaches for the treatment of diseases caused by RV infection (Cong, et al., 2011).
MOG is a glycoprotein (type I integral membrane protein) possessing a single extracellular Ig variable domain. It is expressed mainly in the central nervous system (CNS) where it is believed to be important in the myelination of nerves (Johns & Bernard, 1999; Clements, et al., 2003). It is speculated to serve as a necessary adhesion molecule to provide structural integrity to the myelin sheath and is known to develop late on the oligodendrocyte (Pham-Dinh, et al., 1993). MOG also binds C1q and so may have an immune-related function as a regulator of the classical complement pathway (Vanguri & Shin, 1986).
Antibodies to MOG are associated with a subset of inflammatory demyelinating diseases of the central nervous system and myelin injury is thought to be closely related to neurodegenerative diseases. MOG could therefore be an early diagnostic criteria and therapeutic target for these diseases (Wang, et al., 2018).
REFERENCES
- Clements, C. S. et al., 2003. The crystal structure of myelin oligodendrocyte glycoprotein, a key autoantigen in multiple sclerosis. Proc. Natl. Acad. Sci. U. S. A., Volume 100, p. 11059–11064.
- Cong, H., Jiang, Y. & Tien, P., 2011. Identification of the Myelin Oligodendrocyte Glycoprotein as a Cellular Receptor for Rubella Virus. J Virol. , 85(21), p. 11038–11047.
- Pham-Dinh, D. et al., 1993. Myelin/oligodendrocyte glycoprotein is a member of a subset of the immunoglobulin superfamily encoded within the major histocompatibility complex. Proc. Natl. Acad. Sci. U. S. A., Volume 90, p. 7990–7994.
- Vanguri, P. & Shin, M. L., 1986. Activation of complement by myelin: identification of C1-binding proteins of human myelin from central nervous tissue. J. Neurochem., Volume 46, p. 1535–1541.
- Wang, S. S. et al., 2018. Myelin injury in the central nervous system and Alzheimer’s disease. Brain Research Bulletin, Volume 140, pp. 162-168.
Johns , T. G. & Bernard, C. C., 1999. The structure and function of myelin oligodendrocyte glycoprotein. J. Neurochem., Volume 72, pp. 1-9.
Dry ice
ebiomall.com






>
>
>
>
>
>
>
>
>
>
>
>
主要是中度以上细胞免疫缺陷包括:CD4+T淋巴细胞耗竭,外周血淋巴细胞显著减少,CD4<200/μl,CD4/CD8<1.0,(正常人为1.25~2.1),迟发型变态反应皮试阴性,有丝分裂原刺激反应低下。NK细胞活性下降。
2.各种致病性感染的病原体检查
如用PCR方法检测相关病原体,恶性肿瘤的组织病理学检查。
3.HIV抗体检测
采用酶联免疫吸附法、明胶颗粒凝集试验、免疫荧光检测法、免疫印迹检测法、放射免疫沉淀法等,其中前三项常用于筛选试验,后二者用于确证试验。
4.PCR技术检测HIV病毒。
所以说,感染同一种病毒,每个人识别的表位可能不一样。
①乙型肝炎表面抗原—抗体系统(HBsAg/抗—HBs);
②乙型肝炎核心抗原—抗体系统(HBcAg/抗—HBc):
③乙型肝炎e抗原—抗体系统(HBeAg);
④乙型肝炎Dane颗粒抗原—抗体系统
⑤乙型肝炎δ抗原—抗体系统(δ/抗—δ)。
临床意义 1.HBsAg:血清中检测到HBsAg ,表示体内感染了HBV,因而是一种特异性标志。HBsAg阳性见于:①急性乙型肝炎的潜伏期或急性期(大多短期阳性);②HBV致的慢性肝病、迁延性和慢性活动性肝炎、肝炎后肝硬化或原发性肝癌等。③无症状携带者
2.抗HBs:表示曾感染过HBV,不论临床上有无肝炎症状表现,均已得到恢复,并且对HBV有一定的免疫力。
3.HBcAg与抗HBc:由于 HBcAg主要存在于肝细胞核内,并仅存在于Dane颗粒中。因此,对病人血清不能检测HBcAg,而测抗HBc。血清内抗HBc阳性反映:①新近有过HBV感染;②体内有HBV增殖;③有助于诊断急性或慢性乙型肝炎,特别是少数病例就诊时已处于急性恢复期早期,HBsAg已从血中消失,此时血中仅有抗HBc存在,因此,对恢复期患者可作病因追索。
4.HBcAg和抗HBe:HBcAg的存在常表示病人血液有感染性。 HBcAg阳性揭示病人肝脏可能有慢性损害,对预后判断有一定帮助。抗HBe阳性对病人可能有一定的保护力。展开
1.在手机上下载360手机卫士。
2.下载完成手机卫士之后,在手机中安装360手机卫士。在手机中打开360手机卫士并授予手机卫士 Root 权限,如图所示。
3.在手机卫士主界面打开“应用工具”选项,进入后找到“一键 Root 工具”并打开。如果手机已经获取 Root 权限,手机卫士会提示已经手机获取 Root 权限,可以解除 Root 了。
4.点击“解除 Root”按钮之后,360 Root 工具就会给出提示,“注意!解除 Root 之后将永久失去 Root 权限,并且可能无法重新获取!因此若非送修等特殊需要,不建议解除......”确认后点击“解除 Root”按钮即可解除 Root 权限。
方法二:恢复手机的出厂设置。
1.在待机页面下,点击【应用程序】。
2.点击【设定】。
3.向上滑动手机屏幕,点击【重置】。
4.点击【恢复出厂设定】。
5.点击【重置设备】。
6.点击【全部删除】。
7.完成操作后,待手机自动重启后,手机就成功恢复出厂设定了。
患者,双手扶墙,脚尖着地;医生做好消毒,戴上手套,利用放血针(可以利用测血糖的放血针),在委中穴点刺放血,利用拔罐器把瘀血抽出来,直到见到新鲜血液为止。委中穴是解毒大穴。
中医强调治症不治病,虽然身体还有病毒,但是,只要症状能够解除,不影响正常生活和工作,就可以了。
需要强调:医生,一定要做好消毒、保护,防止病毒感染。 另外,可以把艾滋病作为一种疫病,尝试五苓散;五苓散是用来治疗疫病的。
1、存在于细胞外环境时,不显复制活性,但保持感染活性,是病毒体或病毒颗粒形式。
2、抗原,是指能够刺激机体产生(特异性)免疫应答,并能与免疫应答产物抗体和致敏淋巴细胞在体外结合,发生免疫效应(特异性反应)的物质