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Description:Reversetranscriptaseinhibitor;antiretroviral
ChemicalName:(1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanolhemisulfate
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Competitivereversetranscriptaseinhibitor;inhibitsHIVreplication.Orallyactiveandbrainpenetrant.Antiretroviralagent.
LicensingInformation
SoldforresearchpurposesunderagreementfromViiv.
CompoundLibraries
AbacavirhemisulfateisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 335.37 |
| Formula | C14H18N6O.½H2SO4 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 188062-50-2 |
| PubChemID | 75539558 |
| InChIKey | WMHSRBZIJNQHKT-NHMRBCHTSA-N |
| Smiles | OS(O)(=O)=O.NC1=NC(NC2CC2)=C2N=CN(C3C[C@H](CO)C=C3)C2=N1.NC1=NC(NC2CC2)=C2N=CN(C3C[C@H](CO)C=C3)C2=N1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 16.77 | 50 | |
| water | 33.54 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight335.37.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.98mL | 14.91mL | 29.82mL |
| 5mM | 0.6mL | 2.98mL | 5.96mL |
| 10mM | 0.3mL | 1.49mL | 2.98mL |
| 50mM | 0.06mL | 0.3mL | 0.6mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet

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