Tocris试剂采购生命科学Tocris Bioscience价格优惠,Tocris/Mithramycin A/1489/1/1 mg,DNA聚合酶,核酸酶类,分子类,,Tocris Bioscience蚂蚁淘商城

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Tocris/Mithramycin A/1489/1/1 mg

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Tocris

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1489/1

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4000-520-616

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Description:InhibitorofDNAandRNApolymerase

ChemicalName:(1S)-5-Deoxy-1-C-[(2S,3S)-7-[[2,6-dideoxy-3-O-(2,6-dideoxy-β-D-arABIno-hexopyranosyl)-β-D-arabino-hexopyranosyl]oxy]-3-[(O-2,6-dideoxy-3-C-methyl-β-D-ribo-hexopyranosyl-(1.fwdarw.3)-O-2,6-dideoxy-β-D-lyxo-hexopyranosyl-(1.fwdarw.3)-2,6-dideoxy-β-D-arabino-hexopyranosyl)oxy]-1,2,3,4-tetrahydro-5,10-dihydroxy-6-methyl-4-oxo-2-anthracenyl]-1-O-methyl-D-threo-2-pentulose

Purity:≥95%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

AnticancerantibioticthatselectivelybindstoG-C-richDNAinthepresenceofMg²⁺orZn²⁺,inhibitingRNAandDNApolymeraseaction.Inhibitsc-mycexpressionandinducesmyeloiddifferentiationofHL-60promyelocyticleukemiacells.

TechnicalData

M.Wt	1085.16
Formula	C₅₂H₇₆O₂₄
Storage	Desiccateat-20°C
Purity	≥95%(HPLC)
CASNumber	18378-89-7
PubChemID	90479798
InChIKey	CFCUWKMKBJTWLW-YZCDWGPJSA-N
Smiles	OC1=C2C(C=C3C(C([C@@H](OC5OC(C)C(O)C(OC6OC(C)C(O)C(OC7OC(C)C(O)C(O)(C)C7)C6)C5)[C@@]([C@H](OC)C([C@@H](O)[C@H](O)C)=O)([H])C3)=O)=C2O)=CC(O[C@@H]4OC(C)C(O)C(OC8OC(C)C(O)C(O)C8)C4)=C1C

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	54.26	50

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight1085.16.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	0.92mL	4.61mL	9.22mL
5mM	0.18mL	0.92mL	1.84mL
10mM	0.09mL	0.46mL	0.92mL
50mM	0.02mL	0.09mL	0.18mL

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BiologicalActivity

TechnicalData

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