Tocris美元价/进货价 Tocris Bioscience批发，产品货源,Tocris/AZD 2461/6060/50/50 mg,DNA聚合酶,核酸酶类,分子类,,Tocris Bioscience蚂蚁淘商城

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Tocris/AZD 2461/6060/50/50 mg

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Tocris

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6060/50

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4000-520-616

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Description:PotentPARPinhibitor;orallybioavailable

ChemicalName:4-[[4-Fluoro-3-[(4-methoxy-1-piperidinyl)carbonyl]phenyl]methyl]-1(2H)-phthalazinone

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentPARPinhibitor(IC₅₀valuesare2,5and200nMforPARP2,PARP1andPARP3,respectively).ExhibitsanticancereffectsinBRCA1mutant,butnotwild-typebreastcancercelllinesinvitro.Inhibitsgrowthofolaparib-resistantmammarytumorsinamousemodelandisapoorsubstratefortheP-gptransporter.Orallybioavailable.

TechnicalData

M.Wt	395.43
Formula	C₂₂H₂₂FN₃O₃
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	1174043-16-3
PubChemID	44199317
InChIKey	HYNBNUYQTQIHJK-UHFFFAOYSA-N
Smiles	COC1CCN(C(C2=C(C=CC(CC3=NNC(C4=CC=CC=C34)=O)=C2)F)=O)CC1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	39.54	100
	ethanol	39.54	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight395.43.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.53mL	12.64mL	25.29mL
5mM	0.51mL	2.53mL	5.06mL
10mM	0.25mL	1.26mL	2.53mL
50mM	0.05mL	0.25mL	0.51mL

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