进口Tocris品牌清关代理中国Tocris Bioscience官网，价格更新,Tocris/AZ 6102/5775/10/10 mg,DNA聚合酶,核酸酶类,分子类,,Tocris Bioscience蚂蚁淘商城

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Tocris/AZ 6102/5775/10/10 mg

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Tocris

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5775/10

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4000-520-616

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Description:PotentTNKS1/2inhibitor

ChemicalName:rel-2-[4-[6-[(3R,5S)-3,5-Dimethyl-1-piperazinyl]-4-methyl-3-pyridinyl]phenyl]-3,7-dihydro-7-methyl-4H-pyrrolo[2,3-d]pyrimidin-4-one

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentTNKS2andTNKS1inhibitor(IC₅₀valuesare1and3nM,respectively).Exhibits>100-foldselectivityforTNKS1/2overPARP-1,PARP-2andPARP-6.InhibitsWntsignalinginDLD-1cells(IC₅₀=5nM).ExhibitsmoderateoralbioavailABIlity.

ExternalPortalInformation

Chemicalprobes.orgisaportalthatoffersindependentguidanceontheselectionand/orapplicationofsmallmoleculesforresearch.TheuseofAZ6102isreviewedonthechemicalprobeswebsite.

CompoundLibraries

AZ6102isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	428.53
Formula	C₂₅H₂₈N₆O
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	1645286-75-4
PubChemID	91663328
InChIKey	WCPTUQOMNJBIET-CALCHBBNSA-N
Smiles	CC1=CC(N2C[C@H](C)N[C@H](C)C2)=NC=C1C3=CC=C(C(N4)=NC5=C(C=CN5C)C4=O)C=C3

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	21.43	50

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight428.53.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.33mL	11.67mL	23.34mL
5mM	0.47mL	2.33mL	4.67mL
10mM	0.23mL	1.17mL	2.33mL
50mM	0.05mL	0.23mL	0.47mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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