![Signalchem/TNFB siRNA Set I/20 nmol/T861-911-20](images/Signalchem/smallvial.jpg)
Overview:
TNFB is a member of the tumor necrosis factor cytokine family that is primarily expressed on lymphocytes that control lipid metabolism. TNFB is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. TNF-beta acts as a novel therapeutic route for the treatment of dyslipidemia (1). The presence of TNFB accelerates the initiation of immune responses and protects the host from larger viral challenges (2).
Gene Aliases:
TNF-B; LT; TNFSF1; LTA
Genbank Number:
AAH34729.1
References:
1. Lo, J. C. et.al: Lymphotoxin beta receptor-dependent control of lipid homeostasis. Science 316: 285-288, 2007. 2. Lund, F. E. et.al: Lymphotoxin-alpha-deficient mice make delayed, but effective, T and B cell responses to influenza. J. Immun. 169: 5236-5243, 2002.
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1970科家致癌RNA病毒发现种特殊RNA病毒聚合酶,该酶能RNA模板,根据碱基互补原则.程与般病毒转录向相反,故称逆转录,催化程酶称逆转录酶,发现哺乳物胚胎细胞裂淋巴细胞含.
逆转录病毒称携带逆转录酶病毒,先侵入宿主细胞病毒RNA模板,靠酶形DNA环化,合宿主细胞染色体原病毒形式宿主细胞代代传.
HIV(艾滋病病毒)典型逆转录病毒
⒈通过嵌入DNA双链的碱基之间,形成稳定复合物,抑制DNA复制与RNA合成,从而阻碍快速生长的癌细胞的分裂。
⒉抑制拓扑异构酶II,影响DNA超螺旋转化成为松弛状态,从而阻碍DNA复制与转录。有研究显示拓扑异构酶II抑制剂(除蒽环类药物还包括依托泊苷等)能够阻止拓扑异构酶II的翻转,而这点对于它从它的核酸底物上脱离是必需的。这就意味着,拓扑异构酶II抑制剂使拓扑异构酶II的复合物在DNA链断裂之后才能更稳定,导致后者催化了DNA的破坏;同时,拓扑异构酶II抑制剂还能阻碍连接酶对DNA的修复。
⒊螯合铁离子后产生自由基从而破坏DNA、蛋白质及细胞膜结构。向左转|向右转
最近遇到了实验上的大问题,就是用一步法做RNA的荧光定量PCR时,发现低浓度的做不出来,而DNA是可以的,想请问各位在一步法PCR中有没有什么高见,就是逆转录的Buffer有没有什么需要注意的地方!就是在逆转录酶的最适Buffer和Taq酶的最适Buffer中寻找一个最适的Buffer!
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