BiologicalActivity
Thalidomideanalog.Immunemodulatorydrugandcereblonbindingcompound.Inducesubiquitinationanddegradationofcaseinkinase(CK)1αbytheE3ubiquitinligaseCRL4CRBN.AlsoTNF-αinhibitorandangiogenesisinhibitor.
TechnicalData
| M.Wt | 259.26 |
| Formula | C13H13N3O3 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 191732-72-6 |
| PubChemID | 216326 |
| InChIKey | GOTYRUGSSMKFNF-UHFFFAOYSA-N |
| Smiles | NC1=C2CN(C(C2=CC=C1)=O)C3CCC(NC3=O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 25.93 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight259.26.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.86mL | 19.29mL | 38.57mL |
| 5mM | 0.77mL | 3.86mL | 7.71mL |
| 10mM | 0.39mL | 1.93mL | 3.86mL |
| 50mM | 0.08mL | 0.39mL | 0.77mL |
MolarityCalculator
ReconstitutionCalculator
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.
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