Tocris经销商/代理商 Tocris Bioscience一级代理,Tocris/HLI 373/3503/50/50 mg,连接酶,核酸酶类,分子类,,Tocris Bioscience蚂蚁淘商城

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Tocris/HLI 373/3503/50/50 mg

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Tocris

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3503/50

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4000-520-616

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Description:Hdm2inhibitor;activatesp53-dependenttranscription

ChemicalName:5-[[3-Dimethylamino)propyl]amino]-3,10-dimethylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dionedihydrochloride

Purity:≥99%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

InhibitorofHdm2ubiquitinligase(E3).BlocksHdm2-mediatedubiquitylationandproteasomaldegradationofp53;activatesp53-dependenttranscription.Inducesapoptosisinseveraltumorcelllinesthatexpresswild-typep53suchasLOX-IMVI,A549,HT1080andU2OS.

TechnicalData

M.Wt	414.33
Formula	C₁₈H₂₃N₅O₂.2HCl
Storage	DesiccateatRT
Purity	≥99%(HPLC)
CASNumber	502137-98-6
PubChemID	72193867
InChIKey	WUEMKAQTAIRDOA-UHFFFAOYSA-N
Smiles	CN2C1=CC=CC=C1C(NCCCN(C)C)=C3C2=NC(N(C)C3=O)=O.Cl.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	3.78	10
	water	37.79	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight414.33.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.41mL	12.07mL	24.14mL
5mM	0.48mL	2.41mL	4.83mL
10mM	0.24mL	1.21mL	2.41mL
50mM	0.05mL	0.24mL	0.48mL

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TechnicalData

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PreparingStockSolutions

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