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Description:Hdm2inhibitor;activatesp53-dependenttranscription
ChemicalName:5-[[3-Dimethylamino)propyl]amino]-3,10-dimethylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dionedihydrochloride
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
InhibitorofHdm2ubiquitinligase(E3).BlocksHdm2-mediatedubiquitylationandproteasomaldegradationofp53;activatesp53-dependenttranscription.Inducesapoptosisinseveraltumorcelllinesthatexpresswild-typep53suchasLOX-IMVI,A549,HT1080andU2OS.
TechnicalData
M.Wt | 414.33 |
Formula | C18H23N5O2.2HCl |
Storage | DesiccateatRT |
Purity | ≥99%(HPLC) |
CASNumber | 502137-98-6 |
PubChemID | 72193867 |
InChIKey | WUEMKAQTAIRDOA-UHFFFAOYSA-N |
Smiles | CN2C1=CC=CC=C1C(NCCCN(C)C)=C3C2=NC(N(C)C3=O)=O.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 3.78 | 10 | |
water | 37.79 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight414.33.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.41mL | 12.07mL | 24.14mL |
5mM | 0.48mL | 2.41mL | 4.83mL |
10mM | 0.24mL | 1.21mL | 2.41mL |
50mM | 0.05mL | 0.24mL | 0.48mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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