BiologicalActivity
DNAligaseI,IIIandIVinhibitor(IC50valuesare5,9and5μMrespectively)thatblocksDNAbinding(Ki=5μMforDNAligaseI).Preferentiallyinhibitsstep2oftheligationreaction,andinhibitsbaseexcisionrepair(BER)andnon-homologousendjoining(NHEJ).SpecificallysensitizescancercellstoDNAdamageandincreasesthecytotoxicityofDNA-damagingagents.
TechnicalData
| M.Wt | 246.29 |
| Formula | C11H10N4OS |
| Storage | Storeat-20°C |
| CASNumber | 64232-83-3 |
| PubChemID | 824710 |
| InChIKey | SAKOXVNKDMWWLF-UHFFFAOYSA-N |
| Smiles | S=C1NC(N)=C(/N=C/C2=CC=CC=C2)C(N1)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.63 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight246.29.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 4.06mL | 20.3mL | 40.6mL |
| 5mM | 0.81mL | 4.06mL | 8.12mL |
| 10mM | 0.41mL | 2.03mL | 4.06mL |
| 50mM | 0.08mL | 0.41mL | 0.81mL |
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