正品Tocris生物试剂1 Tocris化合物筛选文库,Tocris/PTC 209/5191/10/10 mg,连接酶,核酸酶类,分子类,,Tocris Bioscience蚂蚁淘商城

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Tocris/PTC 209/5191/10/10 mg

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Tocris

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5191/10

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4000-520-616

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Description:Bmi-1inhibitor;antitumor

ChemicalName:N-(2,6-Dibromo-4-methoxyphenyl)-4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)-2-thiazolamine

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Bmi-1inhibitor(IC₅₀~0.5μM);irreversIBLyimpairscolorectalcancer-initiatingcell(CIC)growth.ReducestumorgrowthinCICxenograftassaysandresultsinreducedpotentialofcolorectalcancercellstoinitiatetumorsinvivo.

TechnicalData

M.Wt	495.19
Formula	C₁₇H₁₃Br₂N₅OS
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	315704-66-6
PubChemID	1117196
InChIKey	XVOOCQSWCCRVDY-UHFFFAOYSA-N
Smiles	CC3=C(N(C=CC=N4)C4=N3)C1=CSC(NC2=C(Br)C=C(OC)C=C2Br)=N1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	49.52	100
	ethanol	9.9	20

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight495.19.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.02mL	10.1mL	20.19mL
5mM	0.4mL	2.02mL	4.04mL
10mM	0.2mL	1.01mL	2.02mL
50mM	0.04mL	0.2mL	0.4mL

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