BiologicalActivity
Ubiquitin-activatingenzyme(E1)inhibitor.Blocksdegradationofp53andcyclinD3.InhibitsNF-κBactivationandinducescelldeathassociatedwithERstress.Displaysantitumoreffectsinamousemodelofleukemia.
TechnicalData
| M.Wt | 351.67 |
| Formula | C14H7ClFN3O5 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 423148-78-1 |
| PubChemID | 60111983 |
| InChIKey | MSYMKEYWUWVZQY-TWGQIWQCSA-N |
| Smiles | FC(C=C3)=C(Cl)C=C3N(C(/C1=CC2=CC=C([N+]([O-])=O)O2)=O)NC1=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.17 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight351.67.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.84mL | 14.22mL | 28.44mL |
| 5mM | 0.57mL | 2.84mL | 5.69mL |
| 10mM | 0.28mL | 1.42mL | 2.84mL |
| 50mM | 0.06mL | 0.28mL | 0.57mL |
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