Tocris厂家直采，平行进口 Tocris信号通路抑制剂,Tocris/SKPin C1/4817/10/10 mg,连接酶,核酸酶类,分子类,,Tocris Bioscience蚂蚁淘商城

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Tocris/SKPin C1/4817/10/10 mg

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Tocris

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4817/10

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Description:InhibitsSkp2-mediatedp27degradation;inducescellcyclearrest

ChemicalName:2-[4-Bromo-2-[[4-oxo-3-(3-pyridinylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]phenoxy]aceticacid

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

InhibitorofSkp2-mediatedp27degradation.Inducesp27accumulationinmetastaticmelanomacelllines.PromotesG₁/ScellcyclearrestinT47DcellsandLNCaPcells;inducesG₂/McellcyclearrestinMCF-7cells.

TechnicalData

M.Wt	465.34
Formula	C₁₈H₁₃BrN₂O₄S₂
Storage	Storeat+4°C
Purity	≥98%(HPLC)
CASNumber	432001-69-9
PubChemID	5733396
InChIKey	IYCJJVVXEHZJHE-CHHVJCJISA-N
Smiles	BrC1=CC=C(OCC(O)=O)C(/C=C2SC(N(CC3=CN=CC=C3)C2=O)=S)=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	4.65	10

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight465.34.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.15mL	10.74mL	21.49mL
5mM	0.43mL	2.15mL	4.3mL
10mM	0.21mL	1.07mL	2.15mL
50mM	0.04mL	0.21mL	0.43mL

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