BiologicalActivity
Skp2inhibitor;thoughttopreventassemblyofSkp2-Skp1complexes.SelectivelysuppressesSkp2SCFE3ligaseactivitybutexhibitsnoeffectontheactivityofotherSCFcomplexes.AlsoinhibitsSkp2-mediatedp27andAktubiquitinationinvivoandinvitro.Suppressesthesurvivalofcancercellsandcancerstemcellsbytriggeringcellsenescenceandinhibitingglycolysis.Exhibitsantitumoreffectsinmultipleanimalmodelsandcancercelllines.
TechnicalData
| M.Wt | 420.52 |
| Formula | C24H24N2O3S |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 222716-34-9 |
| PubChemID | 1286902 |
| InChIKey | JKIXLEKBXHMXTN-UHFFFAOYSA-N |
| Smiles | OC(C(CC)=C2)=C(CN3CCCCC3)C1=C2C(C(C4=NC5=C(C=CC=C5)S4)=CO1)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| 1eq.HCl | 8.41 | 20 | |
| DMSO | 2.1 | 5mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight420.52.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.38mL | 11.89mL | 23.78mL |
| 5mM | 0.48mL | 2.38mL | 4.76mL |
| 10mM | 0.24mL | 1.19mL | 2.38mL |
| 50mM | 0.05mL | 0.24mL | 0.48mL |
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