BiologicalActivity
p210bcr/abltyrosinekinaseinhibitor(IC50=14μM).InducesapoptosisinT-lymphoblastichumanleukemiacelllines(IC50valuesrangefrom16.8to216.3nM)invitro.Displaysselectivityforchronicmyelogenousleukemia(CML)myeloidProgenitorsinvitro.
TechnicalData
| M.Wt | 393.48 |
| Formula | C24H27NO4 |
| Storage | Desiccateat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 241127-58-2 |
| PubChemID | 387042 |
| InChIKey | YJZSUCFGHXQWDM-UHFFFAOYSA-N |
| Smiles | O=C(C4=CC=C(NCC5=C(O)C=CC(O)=C5)C=C4)OC12CC(C3)CC(CC3C2)C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.35 | 100 | |
| ethanol | 39.35 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight393.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.54mL | 12.71mL | 25.41mL |
| 5mM | 0.51mL | 2.54mL | 5.08mL |
| 10mM | 0.25mL | 1.27mL | 2.54mL |
| 50mM | 0.05mL | 0.25mL | 0.51mL |
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