BiologicalActivity
PotentandselectiveirreversibleMAGLinhibitor(IC50valuesare0.25and7.4nMatrMAGLandhMAGL,respectively).Exhibits389-foldselectivityoverhFAAHandexhibitsminimalbindingatCBreceptors(IC50>10μM).AlleviatessymptomsinaMSinvivomodel.Exhibitsanalgesiceffectsinanacuteinflammatorypainmodelinvivo.Amelioratesneuropathichypersensitivityinducedbyoxaliplatin(Cat.No.2623).DisplayshighmembranepermeABIlityandbrainpenetrant.
TechnicalData
| M.Wt | 463.46 |
| Formula | C24H22FN5O4 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1881244-28-5 |
| Smiles | FC1=CC=C([C@@H]2[C@@H](C3=CC=C4OCOC4=C3)N(C2=O)C5CCN(C(N6C=NC=N6)=O)CC5)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.35 | 100 | |
| ethanol | 23.17 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight463.46.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.16mL | 10.79mL | 21.58mL |
| 5mM | 0.43mL | 2.16mL | 4.32mL |
| 10mM | 0.22mL | 1.08mL | 2.16mL |
| 50mM | 0.04mL | 0.22mL | 0.43mL |
MolarityCalculator
ReconstitutionCalculator
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.
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