BiologicalActivity
Antioxidant,anti-inflammatory,antiproliferativeandantiviralagent.InhibitsLPS-inducediNOSexpressionviainhibitionofIκBαphosphorylationandp65nucleartranslocation(IC50=10nM).InhibitsHIV-1replicationinvitro.AlsopotentlyinhibitsMKK1(MEK1)(IC50=0.5nM)andprovidesneuroprotectionbybindingtokainatereceptors.
CompoundLibraries
ArctigeninisalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 372.42 |
| Formula | C21H24O6 |
| Storage | Desiccateat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 7770-78-7 |
| PubChemID | 64981 |
| InChIKey | NQWVSMVXKMHKTF-JKSUJKDBSA-N |
| Smiles | OC(C=C3)=C(OC)C=C3C[C@@H](C(OC2)=O)[C@H]2CC1=CC(OC)=C(OC)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.24 | 100 | |
| ethanol | 9.31 | 25mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight372.42.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.69mL | 13.43mL | 26.85mL |
| 5mM | 0.54mL | 2.69mL | 5.37mL |
| 10mM | 0.27mL | 1.34mL | 2.69mL |
| 50mM | 0.05mL | 0.27mL | 0.54mL |
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