BiologicalActivity
SelectiveinhibitorofcGMP-stimulatedphosphodiesterase(PDE2)(IC50=0.8-4μM).Alsoapotentinhibitorofadenosinedeaminase.SuppressesspontaneousdifferentiationofhumanESCsinfeeder-freeconditions.Alsopreventsdirectedneuronaldifferentiation.
TechnicalData
| M.Wt | 313.83 |
| Formula | C14H23N5O.HCl |
| Storage | StoreatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 58337-38-5 |
| PubChemID | 11056106 |
| InChIKey | VVDXNJRUNJMYOZ-DHXVBOOMSA-N |
| Smiles | NC1=NC=NC2=C1N=CN2[C@@H](CCCCCC)[C@H](O)C.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.38 | 100 | |
| ethanol | 31.38 | 100 | |
| water | 31.38 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight313.83.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.19mL | 15.93mL | 31.86mL |
| 5mM | 0.64mL | 3.19mL | 6.37mL |
| 10mM | 0.32mL | 1.59mL | 3.19mL |
| 50mM | 0.06mL | 0.32mL | 0.64mL |
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