BiologicalActivity
Potentandselectivelysinespecificdemethylase1(LSD1)inhibitor(IC50=16nM).Exhibits>1000-foldselectivityforLSD1overcloselyrelatedenzymesincludingLSD2,MAO-1andMAO-B.Inhibitscancercelllinegrowthinvitro.
LicensingInformation
ThisprobeissuppliedinconjunctionwiththeStructuralGenomicsConsortium.Forfurthercharacterizationdetails,pleasevisittheGSKLSD1probesummaryontheSGCwebsite.
CompoundLibraries
GSKLSD1dihydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 289.24 |
| Formula | C14H20N2.2HCl |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| PubChemID | 91663353 |
| InChIKey | PJFZOGMSPBHPNS-WICJZZOFSA-N |
| Smiles | C1(N[C@@H]2C[C@H]2[C@]3=CC=CC=C3)CCNCC1.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.92 | 100 | |
| water | 28.92 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight289.24.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.46mL | 17.29mL | 34.57mL |
| 5mM | 0.69mL | 3.46mL | 6.91mL |
| 10mM | 0.35mL | 1.73mL | 3.46mL |
| 50mM | 0.07mL | 0.35mL | 0.69mL |
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