BiologicalActivity
Selectiveinhibitorofcaseinkinase(CK)1δ(IC50valuesare290nM,1.3μMand2.5μMforCK1δ,εandα);displaysnoinhibitoryactivityatCK2.InhibitsCK1δ-dependentphosphorylationanddegradationofPER1protein.ShowntolengthenthecircADIanperiodinU2OScells,withminimaleffectonamplitude.
CompoundLibraries
LH846isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxII.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 316.81 |
| Formula | C16H13ClN2OS |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 639052-78-1 |
| PubChemID | 851474 |
| InChIKey | DYHAMRNAHTWYKY-UHFFFAOYSA-N |
| Smiles | O=C(CC3=CC=CC=C3)NC(S2)=NC1=C2C=C(C)C(Cl)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.68 | 100 | |
| ethanol | 1.58 | 5mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight316.81.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.16mL | 15.78mL | 31.56mL |
| 5mM | 0.63mL | 3.16mL | 6.31mL |
| 10mM | 0.32mL | 1.58mL | 3.16mL |
| 50mM | 0.06mL | 0.32mL | 0.63mL |
MolarityCalculator
ReconstitutionCalculator
DilutionCalculator
ProductDatasheets
© 2005- 苏州蚂蚁淘生物科技有限公司 版权所有。
苏ICP备17049038号-11
苏公网安备 32059002001627号
声明：本网站部分产品受外界条件影响（包含但不限于进口国出口国政策限制等因素），无法提供销售服务，下单后，会由客服人员联系厂家确认后另行通知。部分危险品无法清关，请勿下单
我要提问
您的问题将推送给已购用户，TA们将会为你解答。