BiologicalActivity
Highaffinitygroup1PAK(pan-PAK1,2and3)inhibitor(Ki=3.7nM;pMEKIC50=69nM).Of235kinasestested,otherthanPAK1,eight(PAK2,PAK3,KHS1,Lck,MST3,MST4,SIK2,andYSK1)wereinhibited>70%.ExhibitslowhERGchannelactivity(<50%inhibitionat10μM).Orallybioavailable.
Chemicalprobes.orgisaportalthatoffersindependentguidanceontheselectionand/orapplicationofsmallmoleculesforresearch.TheuseofG5555isreviewedonthechemicalprobeswebsite.
TechnicalData
| M.Wt | 492.96 |
| Formula | C25H25ClN6O3 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1648863-90-4 |
| Smiles | CNC1=NC=C2C=C(C3=C(C=C(C4=CC=CC(C)=N4)C=C3)Cl)C(N(C2=N1)C[C@H]5OC[C@@H](CO5)N)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| 1eq.HCl | 49.3 | 100 | |
| DMSO | 9.86 | 20mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight492.96.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.03mL | 10.14mL | 20.29mL |
| 5mM | 0.41mL | 2.03mL | 4.06mL |
| 10mM | 0.2mL | 1.01mL | 2.03mL |
| 50mM | 0.04mL | 0.2mL | 0.41mL |
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