BiologicalActivity
CytochromeP450inhibitor.Blocksglucocorticoidsynthesisviainhibitionofsteroid11-βhydroxylase(CYP11B1)activity(IC50=7.83μM).AlsoinhibitsCYP3A4andcytochromeP450-mediatedω/ω-1hydroxylaseactivity.
CompoundLibraries
MetyraponeisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 226.27 |
| Formula | C14H14N2O |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 54-36-4 |
| PubChemID | 4174 |
| InChIKey | FJLBFSROUSIWMA-UHFFFAOYSA-N |
| Smiles | O=C(C2=CN=CC=C2)C(C)(C)C1=CC=CN=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 22.63 | 100 | |
| ethanol | 22.63 | 100 | |
| water | 22.63 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight226.27.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 4.42mL | 22.1mL | 44.19mL |
| 5mM | 0.88mL | 4.42mL | 8.84mL |
| 10mM | 0.44mL | 2.21mL | 4.42mL |
| 50mM | 0.09mL | 0.44mL | 0.88mL |
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