BiologicalActivity
TypeIIDNAtopoisomeraseinhibitor.DisruptsDNAsynthesisandrepairandinducesdamagebyDNAcross-linking.AlsoinhibitsPIM1kinase(IC50=51nM).Immunomodulatory,antineoplasticandchemotherapeuticagent.AlsoUSP11inhibitor(IC50=3.15μM).Inducescelldeathofpancreaticcancercelllinesexpressingwild-typeBRCA2.
CompoundLibraries
MitoxantronedihydrochlorideisalsoofferedaspartoftheTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 517.4 |
| Formula | C22H28N4O6.2HCl |
| Storage | DesiccateatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 70476-82-3 |
| PubChemID | 51082 |
| InChIKey | ZAHQPTJLOCWVPG-UHFFFAOYSA-N |
| Smiles | O=C2C3=C(C(O)=CC=C3O)C(C1=C(NCCNCCO)C=CC(NCCNCCO)=C12)=O.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.8 | 75 | |
| water | 2.59 | 5 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight517.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.93mL | 9.66mL | 19.33mL |
| 5mM | 0.39mL | 1.93mL | 3.87mL |
| 10mM | 0.19mL | 0.97mL | 1.93mL |
| 50mM | 0.04mL | 0.19mL | 0.39mL |
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