BiologicalActivity
JARID1(JumonjiAT-RichInteractiveDomain1)inhibitor(IC50valuesare3,4.9and6μMforJARID1B,1Aand1C,respectively).SelectiveforJARID1overUTXandJMJD3.IncreaseslevelsofmethylatedH3K4inJARIDB1-transfectedHeLacellsandMCF7cells.InhibitsproliferationofbreastcancercelllinesexpressinghighlevelsofJARIDB1.
TechnicalData
| M.Wt | 241.31 |
| Formula | C14H11NOS |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 2514-30-9 |
| PubChemID | 935415 |
| InChIKey | KRXMYBAZKJBJAB-UHFFFAOYSA-N |
| Smiles | CC1=CC=C(N2SC3=C(C2=O)C=CC=C3)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.13 | 100 | |
| ethanol | 4.83 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight241.31.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 4.14mL | 20.72mL | 41.44mL |
| 5mM | 0.83mL | 4.14mL | 8.29mL |
| 10mM | 0.41mL | 2.07mL | 4.14mL |
| 50mM | 0.08mL | 0.41mL | 0.83mL |
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