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Tocris/Sildenafil citrate/3784/50/50 mg

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Tocris

货号 /

3784/50

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4000-520-616

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Description:Orallyactive,potentPDE5inhibitor

ChemicalName:1-[[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazinecitrate

Purity:≥99%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Orallyactive,potentinhibitorofphosphodiesterase5(PDE5)(IC₅₀=4nM).Enhancesnitricoxide-dependentrelaxationofhumancorpuscavernosuminvitro.

LicensingInformation

SoldforresearchpurposesunderagreementfromPfizerInc.

CompoundLibraries

SildenafilcitrateisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	666.7
Formula	C₂₂H₃₀N₆O₄S.C₆H₈O₇
Storage	DesiccateatRT
Purity	≥99%(HPLC)
CASNumber	171599-83-0
PubChemID	62853
InChIKey	DEIYFTQMQPDXOT-UHFFFAOYSA-N
Smiles	O=C(O)C(O)(CC(O)=O)CC(O)=O.CN1CCN(S(C2=CC=C(OCC)C(C(NC4=C3N(C)N=C4CCC)=NC3=O)=C2)(=O)=O)CC1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	66.67	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight666.7.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.5mL	7.5mL	15mL
5mM	0.3mL	1.5mL	3mL
10mM	0.15mL	0.75mL	1.5mL
50mM	0.03mL	0.15mL	0.3mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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