BiologicalActivity
ClassIHDACinhibitor(IC50valuesare0.06,0.1,0.5and1.5μMforHDACs3,2,1and8,respectively).Exhibits>6-foldselectivityoverotherHDACs.InducesaccumulationofacetylatedhistonesinHCT116cellsinvitro.Inhibitsproliferationofarangeofcancercelllines.ArrestscellsatG1/Stransition.
CompoundLibraries
UF010isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 271.15 |
| Formula | C11H15BrN2O |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 537672-41-6 |
| PubChemID | 4596836 |
| InChIKey | BVQCFCYPFJOOAV-UHFFFAOYSA-N |
| Smiles | BrC1=CC=C(C(NNCCCC)=O)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.11 | 100 | |
| ethanol | 27.11 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight271.15.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.69mL | 18.44mL | 36.88mL |
| 5mM | 0.74mL | 3.69mL | 7.38mL |
| 10mM | 0.37mL | 1.84mL | 3.69mL |
| 50mM | 0.07mL | 0.37mL | 0.74mL |
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