BiologicalActivity
IrreversibleTrxRinhibitor(IC50=0.62μM).Exhibitsconcentration-,time-andNADH-dependentTrxRinhibition.ResultsintheoxidationofTrxandreducedTrxRactivityinvitroinadditiontotheaccumulationofcellsinsub-G1phase.Reducesneoplastictransformationandinducescelldeathincancercelllines.Chemotherapeutic.
TechnicalData
| M.Wt | 318.24 |
| Formula | C15H10O8 |
| Storage | Storeat-20°C |
| Purity | ≥97%(HPLC) |
| CASNumber | 529-44-2 |
| PubChemID | 5281672 |
| InChIKey | IKMDFBPHZNJCSN-UHFFFAOYSA-N |
| Smiles | OC1=CC(O)=C2C(OC(C3=CC(O)=C(C(O)=C3)O)=C(C2=O)O)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.82 | 100 | |
| ethanol | 15.91 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight318.24.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.14mL | 15.71mL | 31.42mL |
| 5mM | 0.63mL | 3.14mL | 6.28mL |
| 10mM | 0.31mL | 1.57mL | 3.14mL |
| 50mM | 0.06mL | 0.31mL | 0.63mL |
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