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USP7isacysteineprotease,belongstothefamilyofubiquitin-specificproteases.USP7wasfirstdiscoveredasabindingenzymetotheHerpessimplexviralprotein.StudieshaveshownthatUSP7coulddeubiquitinatetheautoubiquitinationofanE3
ligasecalledHDM2thatpromotesubiquitinationandsubsequentdegradationofp53.TheUSP7/HDM2/p53interactionresultsinhigherproteinlevelsofHDM2andlowerlevelsofp53.Becauseofitsapparentroleindifferenttypesofpathologies,includinglungandlivercancer,ithasbecomeapossIBLetargetfordrugtherapies.
ligasecalledHDM2thatpromotesubiquitinationandsubsequentdegradationofp53.TheUSP7/HDM2/p53interactionresultsinhigherproteinlevelsofHDM2andlowerlevelsofp53.Becauseofitsapparentroleindifferenttypesofpathologies,includinglungandlivercancer,ithasbecomeapossIBLetargetfordrugtherapies.
AdditionalInformation
| ProductName: | GST-USP7 |
|---|---|
| AlsoKnownAs: | TEF1;HAUSP |
| CatalogNo.: | H5710 |
| Size: | 25µg |
| MolecularWeight: | 128.3kDa |
| Species: | Human |
| Source: | Sf9insectcells |
| Stock: | 20mMTris,150mMNaCl,2mMβME,10%Glycerol |
| Concentration: | Seetubelabel |
| QualityAssurance: | ~90%bySDS-PAGE,seedatasheetforgelimage |
| Storage: | Storeat-80°C;avoidmultiplefreeze-thawcycles |
| PDFDataSheet: | PDFDatasheet,MSDS |
| NCBIRefSeq: | NM_003470 |
| Image(s): | N/A |
| ShippingMethod: | Dryiceshipping |
| References: | 1.EverettRD,etal.(1997)EMBOJ16(7),1519–1530. 2.LiM,etal.(2004)MolCell26(13),879–886.3.CumminsJM,etal(2004)Nature428(6982),1pfollowing486. 4.NicholsonB,etal.(2011)CellBiochemBiophys60(1–2),61–68. |

