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USP16isanactivedeubiquitinatingenzyme(DUB)encodedonchromosome21,trisomyofwhichcausesDown’ssyndrome(DS).USP16isaphosphoprotein,phosphorylationofUSP16controlsitscellularlocalization,butnoeffectonitsDUBactivity.USP16deubiquitinateshistone2A(H2A),throughwhichUSP16mightregulategeneexpressionandcellcycleprogression.IncreasedUSP16proteinlevelsinpeoplewithDSmightcontributetothedevelopmentofcertainphenotypesofDS.
AdditionalInformation
ProductName: | 6xHis-USP16 |
---|---|
AlsoKnownAs: | UBP-M;UBPM |
CatalogNo.: | H6600 |
Size: | 25µg |
MolecularWeight: | 93.5kDa |
Species: | Human |
Source: | Insectcell |
Stock: | 20mMTris,150mMNaCl,2mMβME,10%Glycerol |
Concentration: | Seetubelabel |
QualityAssurance: | >90%bySDS-PAGE,seedatasheetforgelimage |
Storage: | Storeat-80°C;avoidmultiplefreeze-thawcycles |
PDFDataSheet: | PDFDatasheet,MSDS |
NCBIRefSeq: | NM_006447.2 |
Image(s): | H6600image![]() A.DUBactivityassay:15nMUSP16+500nMUb-Rhodamine110.Rhodamine110fluorescencewasmonitoredbyaplatereaderwithexcitation/emissionwavelengthsat480/528nm,respectively. |
ShippingMethod: | Dryiceshipping |
References: | 1.JooHY.,etal.(2007)Nature449,1068. 2.AdornoM.,etal.(2013)Nature501,380. |