BiologicalActivity
Diacylglycerolacyltransferase1(DGAT-1)inhibitor(IC50valuesare7and24nMathumanandmouseDGAT-1respectively)thatisdevoidofactivityatDGAT-2,ACAT1orACAT2.Inducessignificantweightlosswithoutalteringfoodintake,anddecreasesliverandplasmatriglyceridelevelsinvivo.Orallyactive.
CompoundLibraries
A922500isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 428.48 |
| Formula | C26H24N2O4 |
| Storage | Desiccateat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 959122-11-3 |
| PubChemID | 24768261 |
| InChIKey | BOZRFEQDOFSZBV-DHIUTWEWSA-N |
| Smiles | O=[C@]([C@@H]3CCC[C@H]3[C@@](O)=O)C(C=C2)=CC=C2C1=CC=C(NC(NC4=CC=CC=C4)=O)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 21.42 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight428.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.33mL | 11.67mL | 23.34mL |
| 5mM | 0.47mL | 2.33mL | 4.67mL |
| 10mM | 0.23mL | 1.17mL | 2.33mL |
| 50mM | 0.05mL | 0.23mL | 0.47mL |
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