
LifeSensorshasdevelopedTUBE(TandemUbiquitinBindingEntity)technologyforthedetection, characterization andisolationofpolyubiquitylatedproteinsfromcellsandtissueextracts.TUBEscapitalizeonthelinkageofmultipleubiquitininteractingmotifs(UIMs)togeneratereagentswithhighaffinityforpolyubiquitin.TUBEshave100to1000-foldhigheraffinityforpolyubiquitinchainscomparedtomonomer ubiquitinbinding domains(UBDs).TUBEsbothstABIlizeandbindtoubiquitylatedproteins,servingasanindispensabletoolfor ubiquitologists.OurversatilecollectionofTUBEsincludesreagentsfortheisolation/pulldownofpolyubiquitinconjugatesincludebothlinkage-specificandnon-specificreagentsincludingAnti-M1(Linear)TUBE,Anti-K63TUBE,Anti-K48TUBE,andthenon-specificreagentsAnti-UbiquitinTUBE1andTUBE2.
Wehavedi-,tri-,andtetra-M1(linear)ubiquitinsubstratesthatareresistanttocleavagebyOtulin,whichcanbeusedascontrolsorincompetitionbasedexperiments.Additionally,wesellnativelinearchains.OurLUB9antibodycanbeusedtodetectlinearubiquitylatedsubstratesafterpulldownwithTUBES.
ThisproductisprotectedbyoneormoreUSorForeign patents.
Info
Concentration | Lotdependent |
Buffer | PBS,pH7.2;5%glycerol |
Molecularweight | 33.4kDa |
Storage | Stableforupto1yearat-80ºC.Aliquotreagentandavoidrepeatedfreeze/thawcycles. |
Applications
- IsolationandenrichmentofM1-polyubiquitinatedproteinsfromcellandtissueextracts
- Isolationofubiquitylatedproteinsforproteomicstudies
Benefits
- Nanomolardissociationconstant(Kd)forM1-chains
- 1000to10,000-foldpreferenceforM1chainsoverK48-orK63-chains
- Overexpressionofepitope-taggedubiquitinfor pulldowns isnotnecessary
- CompatIBLewithNi+2IMAC,streptavidin,orFLAG®-basedisolationtechnologies,providingflexibilityandspecificity
Documents
ebiomall.com






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DNMT3a,Dnmt3a,DNMT3A三者有何区别呢,在大鼠或者小鼠身上,用来指酶或者基因时,应该如何表达呢?谢谢
请教各位老师,
文献中检测细胞的活性有的用“NADPHdehydrogenase(NADPH脱氢酶)”有的用“NADPHdiaphorase(NADPH黄递酶)”
它们是同一种酶吗?它们的功能是什么?检测它们的活性是否能够评估细胞的活性。
不胜感激
明白了么,少年?

