BiologicalActivity
Non-competitive,cell-permeableinhibitorofproteintyrosinephosphatases(PTPs)(IC50=0.09-1.7μM);displaysirreversIBLeinhibitionthroughcatalysisofthehydrogenperoxide-dependentoxidationofPTP.Enhancesinsulinsignalinginvitroandinsulintoleranceinob/obmiceinvivo.AlsoinhibitsseveralcytochromeP450isoforms(IC50<10μM).
CompoundLibraries
BVT948isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 241.25 |
| Formula | C14H11NO3 |
| Storage | StoreatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 39674-97-0 |
| PubChemID | 6604934 |
| InChIKey | LLPBUXODFQZPFH-UHFFFAOYSA-N |
| Smiles | CC1(C)C(=O)N=C2C1=C(O)C(=O)C1=CC=CC=C21 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 12.06 | 50 | |
| ethanol | 12.06 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight241.25.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 4.15mL | 20.73mL | 41.45mL |
| 5mM | 0.83mL | 4.15mL | 8.29mL |
| 10mM | 0.41mL | 2.07mL | 4.15mL |
| 50mM | 0.08mL | 0.41mL | 0.83mL |
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