BiologicalActivity
γ-secretaseinhibitor;selectivelyinhibitscleavageofamyloidprecursorprotein(APP)overNotch.LowerslevelsofAβ42andAβ40(EC50valuesare12.4and14.8nMrespectivelyincellsexpressinghumanrecombinantAPP).Orallyactive.
LicensingInformation
SoldforresearchpurposesunderagreementfromPfizerInc.
CompoundLibraries
BegacestatisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 391.74 |
| Formula | C9H8ClF6NO3S2 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 769169-27-9 |
| PubChemID | 11269353 |
| InChIKey | PSXOKXJMVRSARX-SCSAIBSYSA-N |
| Smiles | ClC1=CC=C(S(N[C@H](CO)C(C(F)(F)F)C(F)(F)F)(=O)=O)S1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.17 | 100 | |
| ethanol | 39.17 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight391.74.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.55mL | 12.76mL | 25.53mL |
| 5mM | 0.51mL | 2.55mL | 5.11mL |
| 10mM | 0.26mL | 1.28mL | 2.55mL |
| 50mM | 0.05mL | 0.26mL | 0.51mL |
MolarityCalculator
ReconstitutionCalculator
DilutionCalculator
ProductDatasheets
© 2005- 苏州蚂蚁淘生物科技有限公司 版权所有。
苏ICP备17049038号-11
苏公网安备 32059002001627号
声明：本网站部分产品受外界条件影响（包含但不限于进口国出口国政策限制等因素），无法提供销售服务，下单后，会由客服人员联系厂家确认后另行通知。部分危险品无法清关，请勿下单
我要提问
您的问题将推送给已购用户，TA们将会为你解答。