BiologicalActivity
InhibitorofinteractionbetweencalcineurinanditssubstratenuclearfactorofactivatedTcells(NFAT);blocksatthesubstraterecognitionsitebutnotatthecatalyticsite(Kd=0.8mM).InhibitsNFATdephosphorylationandnuclearimport.AlsopreventsinductionofcytokinemRNAsthataredownstreamtargetsofNFAT.
CompoundLibraries
INCA-6isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 284.31 |
| Formula | C20H12O2 |
| Storage | StoreatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 3519-82-2 |
| PubChemID | 230748 |
| InChIKey | GCHPUOHXXCNSQL-UHFFFAOYSA-N |
| Smiles | O=C1C=CC(=O)C2=C1C1C3=C(C=CC=C3)C2C2=C1C=CC=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 5.69 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight284.31.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.52mL | 17.59mL | 35.17mL |
| 5mM | 0.7mL | 3.52mL | 7.03mL |
| 10mM | 0.35mL | 1.76mL | 3.52mL |
| 50mM | 0.07mL | 0.35mL | 0.7mL |
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