BiologicalActivity
SelectiveglutamatecarboxypeptidaseII(GCPII)inhibitor(IC50=90nM).SelectiveforGCPIIoverNMDA,kainateandAMPAglutamatereceptorsandMMP-1,-2,-3,-7,-9,ACEandNEPmetalloproteases.Antinociceptiveinaratmodelofneuropathicpainandprotectsagainstmotorneurondeathinfamilialamyotrophiclateralsclerosismice.Orallybioavailable.
TechnicalData
| M.Wt | 206.26 |
| Formula | C8H14O4S |
| Storage | Storeat-20°C |
| CASNumber | 254737-29-6 |
| PubChemID | 10198171 |
| InChIKey | FNLNSQHJKVQCBP-UHFFFAOYSA-N |
| Smiles | SCCCC(C(O)=O)CCC(O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.63 | 100 | |
| water | 20.63 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight206.26.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 4.85mL | 24.24mL | 48.48mL |
| 5mM | 0.97mL | 4.85mL | 9.7mL |
| 10mM | 0.48mL | 2.42mL | 4.85mL |
| 50mM | 0.1mL | 0.48mL | 0.97mL |
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