Tocris离子通道调控剂 Tocris配体,Tocris/PD 166793/2520/10/10 mg,蛋白酶类,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/PD 166793/2520/10/10 mg

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Tocris

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2520/10

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4000-520-616

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Description:BroadspectrumMMPinhibitor

ChemicalName:N-[(4'-Bromo[1,1'-biphenyl]-4-yl)sulfonyl]-L-valine

Purity:≥99%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

BroadspectrumMMPinhibitor.DisplayshighaffinityforMMP-2,-3and-13(IC₅₀valuesare4,7and8nMrespectively)andexhibits>750-foldselectivityoverMMP-1,-7and-9.Attenuatesleftventricularremodellinganddysfunctioninratmodelofheartfailure.

CompoundLibraries

PD166793isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	412.3
Formula	C₁₇H₁₈BrNO₄S
Storage	Desiccateat+4°C
Purity	≥99%(HPLC)
CASNumber	199850-67-4
PubChemID	9887870
InChIKey	GJOCABIDMCKCEG-INIZCTEOSA-N
Smiles	BrC1=CC=C(C2=CC=C(S(N[C@@H]([C@H](C)C)C(O)=O)(=O)=O)C=C2)C=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	41.23	100
	ethanol	41.23	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight412.3.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.43mL	12.13mL	24.25mL
5mM	0.49mL	2.43mL	4.85mL
10mM	0.24mL	1.21mL	2.43mL
50mM	0.05mL	0.24mL	0.49mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

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PreparingStockSolutions

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