AKT-I-1/AKT-1-1/AKT-I.1, AKT 1-1
Akt-I-1 inhibits only Akt1 (IC50 4.6 microM). Biochem J. 2005 Jan 15;385(Pt 2):399-408. <BP> The compound did not inhibit Akt3 nor mutants lacking the PH (pleckstrin homology) domain at concentrations up to 250 microM. The compound is a reversible inhibitor, and exhibits a linear mixed-type inhibition against ATP and peptide substrate. In addition to inhibiting kinase activity of individual Akt isoforms, both inhibitors (AKT-I-1 & AKT-I-1,2) blocked the phosphorylation and activation of the corresponding Akt isoforms by PDK1 (phosphoinositide-dependent kinase 1). | ![]() |
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Reference material, accompanied by a certificate, one or more of whose property values are certified by a procedure, which established its traceability to an accurate realization of the unit in which the property values are expressed, and for which each certified value is accompanied by an uncertainty at a stated level of confidence. (Brammer StandardBASARMIetc). (ISO Guide 30-1992)
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Reference Materials(RM)
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