
Overview:
TUBB1 or tubulin-beta 1 protein is a major constituent ofmicrotubules. TUBB1 interaction with microtubule-associatedproteins (MAPs) such as tau is fundamental formicrotubule structure and function (1). Previous worksuggested that the "microtubule binding domain" of tau(composed of three or four imperfect 18-amino acidrepeats, separated by 13- or 14-amino acid inter-repeatregions) can bind to the C-terminal ends of both alphaand beta tubulin monomers. Studies revealed that TUBB1is the target of various antitubulin agents used in thetreatment of cancer. Subsequent studies have alsoconcluded that TUBB1 mutations in clinical samples arerare, and unlikely to contribute to drug resistance (2).
References:
1. Chau, M.F. et al: The microtubule-associated protein taucross-links to two distinct sites on each alpha and betatubulin monomer via separate domains.". Biochemistry,1999; 37 (51): 17692-703.2. Berrieman, H.K. et al: Do beta-tubulin mutations have a rolein resistance to chemotherapy?"Lancet Oncol, 2004; 5 (3):158-64.
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二、补体(complement,C)是存在于正常人和动物血清与组织液中的一组经活化后具有酶活性的蛋白质。早在19世纪末Bordet即证实,新鲜血液中含有一种不耐热的成分,可辅助和补充特异性抗体,介导免疫溶菌、溶血作用,故称为补体。补体是由30余种可溶性蛋白、膜结合性蛋白和补体受体组成的多分子系统,故称为补体系统(complementsystem)。根据补体系统各成分的生物学功能,可将其分为补体固有成分、补体调控成分和补体受体(CR)。

