BiologicalActivity
Annexin/lipocortin1-mimeticpeptide;inhibitsleukocyteextravasation.Reducesneutrophiladhesionandemigration,andpromotesdetachmentofneutrophilsfromactivatedmesentericendotheliuminmiceinvivo.
LicensingInformation
SoldunderlicensefromTheWilliamHarveyResearchInstitute
TechnicalData
| M.Wt | 1351.58 |
| Formula | C63H94N14O17S |
| Sequence | AMVSEFLKQAW (Modifications:Ala-1=N-terminalAc) |
| Storage | Desiccateat-20°C |
| CASNumber | 256447-08-2 |
| PubChemID | 90488718 |
| InChIKey | SUDAISORCUBKHK-RCVXMRHOSA-N |
| Smiles | CSCC[C@H](NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solubility | Solubleto1mg/mlin20%acetonitrile/water |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight1351.58.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 0.74mL | 3.7mL | 7.4mL |
| 5mM | 0.15mL | 0.74mL | 1.48mL |
| 10mM | 0.07mL | 0.37mL | 0.74mL |
| 50mM | 0.01mL | 0.07mL | 0.15mL |
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