BiologicalActivity
Selectiveflavivirusinhibitor.Adenosineanalog.Inhibitsdenguevirus(EC50=0.64μM),hepatitisCvirusandcellularentryofZikavirus.ReducesincreasesofcytokinesandNS1andpreventsdeathindengue-infectedmice.Activeinvivo.Orallybioavailable.
TechnicalData
| M.Wt | 290.27 |
| Formula | C13H14N4O4 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1044589-82-3 |
| PubChemID | 44633776 |
| InChIKey | NKRAIOQPSBRMOV-NRMKKVEVSA-N |
| Smiles | NC1=C2C=CN(C2=NC=N1)[C@@H]3O[C@@H]([C@H]([C@@]3(C#C)O)O)CO |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 5.81 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight290.27.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.45mL | 17.23mL | 34.45mL |
| 5mM | 0.69mL | 3.45mL | 6.89mL |
| 10mM | 0.34mL | 1.72mL | 3.45mL |
| 50mM | 0.07mL | 0.34mL | 0.69mL |
MolarityCalculator
ReconstitutionCalculator
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.
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