BiologicalActivity
Potentestrogenreceptorβ(ERβ)agonist(EC50=65nM).Exhibits13-foldselectivityforERβoverERα.Atheroprotective.Protectsagainstt-BHPinducedapoptosisandattenuatesERstressinHUVECs.ActivatesNrf2signalinginvitroandinvivo.Inhibitstumorgrowth.Alsodihydrotestosteroneantagonistinvivo.
TechnicalData
| M.Wt | 242.27 |
| Formula | C15H14O3 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 531-95-3 |
| PubChemID | 91469 |
| InChIKey | ADFCQWZHKCXPAJ-GFCCVEGCSA-N |
| Smiles | OC1=CC=C([C@H]2COC3=CC(O)=CC=C3C2)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.23 | 100 | |
| ethanol | 24.23 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight242.27.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 4.13mL | 20.64mL | 41.28mL |
| 5mM | 0.83mL | 4.13mL | 8.26mL |
| 10mM | 0.41mL | 2.06mL | 4.13mL |
| 50mM | 0.08mL | 0.41mL | 0.83mL |
MolarityCalculator
ReconstitutionCalculator
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.
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