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Description:Inhibitorofactinpolymerization
ChemicalName:(4R)-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxABIcyclo[11.3.1]heptadeca-4,8-dien-15-yl]-2-thiazolidinone
Purity:≥97%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Inhibitorofactinpolymerization.InteractswithG-actinina1:1ratiotoinhibitpolymerizationintoF-actininvitro(IC50valuesare~60and~900nMinabsenceandpresenceofcalfserum,respectively).Marinetoxin.
TechnicalData
| M.Wt | 395.51 |
| Formula | C20H29NO5S |
| Storage | Storeat-20°C |
| Purity | ≥97%(HPLC) |
| CASNumber | 76343-94-7 |
| PubChemID | 3892 |
| InChIKey | NSHPHXHGRHSMIK-UHFFFAOYSA-N |
| Smiles | O=C1/C=C(C)CC/C=C[C@@H](C)CC[C@@H]2C[C@H](C[C@](O)([C@@]3([H])NC(SC3)=O)O2)O1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 19.78 | 50 | |
| ethanol | 19.78 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight395.51.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.53mL | 12.64mL | 25.28mL |
| 5mM | 0.51mL | 2.53mL | 5.06mL |
| 10mM | 0.25mL | 1.26mL | 2.53mL |
| 50mM | 0.05mL | 0.25mL | 0.51mL |
MolarityCalculator
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ReconstitutionCalculator
ReconstitutionCalculator
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