BiologicalActivity
Selectiveinhibitorofintegrinα2β1(EC50=130nMforα2β1bindingtocollagenI).Bindstotheα2Idomain.Exhibitsselectivityforα2β1overintegrinsα3β1,α4β1,α5β1andαv.InhibitsplateletaggregationtocollagenIcoatedcapillariesunderflow.Alsoinhibitsbindingofα2-expressingCHOcellstocollagenIundershearstressconditions.
CompoundLibraries
BTT3033isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 465.5 |
| Formula | C23H20FN5O3S |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1259028-99-3 |
| PubChemID | 49841251 |
| InChIKey | NSLIQOPYDUKWTA-UHFFFAOYSA-N |
| Smiles | FC1=CC=C(N2N=CC(S(N(C3=CC=C(NC(NC4=CC=CC=C4)=O)C=C3)C)(=O)=O)=C2)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.55 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight465.5.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.15mL | 10.74mL | 21.48mL |
| 5mM | 0.43mL | 2.15mL | 4.3mL |
| 10mM | 0.21mL | 1.07mL | 2.15mL |
| 50mM | 0.04mL | 0.21mL | 0.43mL |
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