BiologicalActivity
Cell-permeablesyntheticpeptideinhibitorofBaxconformationalchangeandmitochondrialtranslocation.DesignedbasedontheBax-bindingdomainofhumanKu70.InhibitsBax-mediatedapoptosisinvitro.Showntoinhibitanti-cancerdrug-inducedapoptosisinvitro.Negativecontrol(Cat.No.1787)available.
LicensingInformation
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TechnicalData
| M.Wt | 586.79 |
| Formula | C27H50N6O6S |
| Sequence | VPMLK |
| Storage | Desiccateat-20°C |
| CASNumber | 579492-81-2 |
| PubChemID | 10129115 |
| InChIKey | NHMUTADCTDDWPV-YFNVTMOMSA-N |
| Smiles | [H]N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solubility | Solubleto1mg/mlinwater |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight586.79.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.7mL | 8.52mL | 17.04mL |
| 5mM | 0.34mL | 1.7mL | 3.41mL |
| 10mM | 0.17mL | 0.85mL | 1.7mL |
| 50mM | 0.03mL | 0.17mL | 0.34mL |
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