BiologicalActivity
OriginallydefinedasaselectiveinhibitorofATRandATMkinases.Inducescelldeathinprematurelysenescentbreastcancercells.Decreasesp21CIP1levelsinprematuresenescentMCF-7andHCT-116cells;alsoexhibitsantiproliferativeactivityinarangeofcancercelllines.Blockscamptothecin-inducedp53phosphorylationandprotectscellsfromcamptothecin-inducedapoptosis.
CompoundLibraries
CGK733isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 555.84 |
| Formula | C23H18Cl3FN4O3S |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 905973-89-9 |
| PubChemID | 6605258 |
| InChIKey | HLCDNLNLQNYZTK-UHFFFAOYSA-N |
| Smiles | [O-][N+](=O)C1=CC(NC(=S)NC(NC(=O)C(C2=CC=CC=C2)C2=CC=CC=C2)C(Cl)(Cl)Cl)=CC=C1F |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 55.58 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight555.84.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.8mL | 9mL | 17.99mL |
| 5mM | 0.36mL | 1.8mL | 3.6mL |
| 10mM | 0.18mL | 0.9mL | 1.8mL |
| 50mM | 0.04mL | 0.18mL | 0.36mL |
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